| 摘要 |
The combinations have antibiotic properties and contain a peptide derivative of the general formula <IMAGE> in which R<1> is hydrogen, methyl, hydroxymethyl, a mono-, di- or trihalogenomethyl group; R<2> is a radical characteristic of an alpha -amino acid which normally occurs in proteins, or a lower alkyl or hydroxy-lower-alkyl radical which is characteristic of an alpha -amino acid which does not normally occur in proteins; R<3> is lower alkyl, lower cycloalkyl, lower alkenyl, aryl or aryl- lower-alkyl; R<4> is hydrogen or lower alkyl; n is 2 or 3 and the configurations at C atoms (a) and (b) are R (when R<1> NOTEQUAL H) and L respectively, or a physiologically tolerated salt of a compound of this type, and an antibiotic, and are used in pharmaceutical preparations. |
