Protective HDL particle number evaluations

摘要

Embodiments of the invention are directed to improved discrimination of protective (anti-atherogenic) HDL from atherogenic or non-protective (NP) HDL. The methods, systems and computer program products determine protective high density lipoprotein particle (HDL-P) numbers. The methods include obtaining concentration measurements of at least twenty subpopulations of HDL-P subclasses in a blood plasma or serum sample and calculating a protective HDL-P number using (i) a defined subset of the obtained HDL-P concentration measurements or (ii) a zero or defined weighting factor below 1 for HDL-P concentration measurements for HDL subclasses associated with particle sizes above about 11 nm.

主权项

1. A method of determining the risk of coronary heart disease (CHD) for a subject, comprising:
providing a sample from a subject; measuring by a NMR spectrometer at least twenty HDL-P subpopulations in the sample; calculating, using at least one processor, a protective HDL-P number using either
(i) a defined subset of the HDL-P subpopulation concentration measurements, wherein the defined subset excludes HDL-P subpopulations with particles sizes 11 nm and above; or(ii) a zero or defined weighting factor below 1 for HDL-P concentration measurements for HDL-P subpopulations with particle sizes 11 nm and above; and determining the CHD risk for the subject using the protective HDL-P number.