| 发明名称 |
CELL PENETRATING CONJUGATES AND METHODS OF USE THEREOF |
| 摘要 |
Provided herein are cell penetrating conjugates. The conjugates include a non-cell penetrating protein attached to a phosphorothioate nucleic acid or phosphorothioate polymer backbone, wherein the phosphorothioate nucleic acid or phosphorothioate polymer backbone enhances intracellular delivery of the non-cell penetrating protein. Also provided are compositions and kits comprising the cojugates. |
| 申请公布号 |
US2016317671(A1) |
申请公布日期 |
2016.11.03 |
| 申请号 |
US201615056777 |
申请日期 |
2016.02.29 |
| 申请人 |
City of Hope |
发明人 |
Herrmann Andreas;Yu Hua;Swiderski Piotr Marek;Shively John Ernest;Li Lin |
| 分类号 |
A61K47/48;C07K16/08;C07K16/40;A61K39/44;C07K16/18 |
主分类号 |
A61K47/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A cell penetrating conjugate comprising a non-cell penetrating protein attached to a phosphorothioate nucleic acid, wherein the phosphorothioate nucleic acid enhances intracellular delivery of the non-cell penetrating protein. |
| 地址 |
Duarte CA US |
