Ergoline derivatives, their preparation and therapeutic composition containing them.

摘要

Ergoline derivatives of formula (I) …… wherein R1 represents a hydrogen atom or a methyl group, R2 represents a hydrogen atom or a methoxy group, X represents an oxygen or sulphur atom or a NH or NCH3 group, R3 represents a hydrogen atom, a trifluoromethyl or phenyl group or an alkyl group having from 1 to 4 carbon atoms, R4 represents a hydrogen atom, a methyl or acetyl group or an alkyl group having from 1 to 4 carbon atoms, or R3 and R4 together represent a 3 or 4 membered carbon atom chain, Y represents an electron withdrawing group such as a cyano, nitro, alkylsulphonyl or alkylsulphinyl group or a group of the formula COR5 wherein R5 represents an alkyl group having from 1 to 4 carbon atoms or a phenyl, alkoxy, amino or N-substituted amino group or R5 an R3 together represent a 2 or 3 membered carbon atom chain, R6 represents a hydrocarbon group having from 1 to 4 carbon atoms or a benzyl or phenethyl group, and R7 represents a hydrogen or halogen atom or a methyl or formyl group or a group of the formula SR8 wherein R8 represents an alkyl group having from 1 to 4 carbon atoms or a phenyl group. The pharmaceutically acceptable addition salts and their preparation are disclosed. In form of therapeutical compositions the compounds exhibit useful pharmacological properties.