| 主权项 |
1. A process for the production of a tissue scaffold that is a porous matrix comprising a first phase and a second phase contained within the first phase, the process, comprising:
providing a material for the first phase and the second phase, wherein the material for the first phase is a solid polymer in powder, grain or granule form such that it is able to flow, which can become a sticky semi-solid by a change in temperature, wherein the material for the first phase or the material for the second phase or both the material for the first phase and the material for the second phase comprises a polymer selected from poly(α-hydroxyacids), polylactic or polyglycolic acids, poly-lactide poly-glycolide copolymers, poly-lactide polyethylene glycol (PEG) copolymers, polyesters, poly (ε-caprolactone), poly (3-hydroxybutyrate), poly (s-caproic acid), poly (p-dioxanone), poly (propylene fumarate), poly (ortho esters), polyol/diketene acetals addition polymers, polyanhydrides, poly (sebacic anhydride) (PSA), poly(carboxybiscarboxyphenoxyphenoxyhexane) (PCPP), poly [bis(p-carboxyphenoxy)methane] (PCPM), copolymers of SA, CPP and CPM poly (amino acids), poly (pseudo amino acids), polyphosphazenes, derivatives of poly [(dichloro) phosphazene], poly [(organo) phosphazenes] polymers, polyphosphates, polyethylene glycol polypropylene block copolymers, natural polymers, silk, elastin, chitin, chitosan, fibrin, fibrinogen, polysaccharides (including pectins), alginates, collagen, poly (amino acids), peptides, polypeptides, proteins, co-polymers prepared from the monomers of these polymers or mixtures thereof; adding a plasticizer to the material for the first phase or the material for the second phase or to both the material for the first phase and the material for the second phase, wherein the plasticizer is selected from the group consisting of: polyethylene glycol (PEG), polypropylene glycol, polycaprolactone, low molecular weight oligomers of polyethylene glycol (PEG), polypropylene glycol, and polycaprolactone, adipates, phosphates, phthalates, sabacates, azelates, citrates, poly lactides, and poly lactide-co-glycolide; introducing a particulate material for the second phase into the material for the first phase, and mixing the material for the first phase and the material for the second phase to form a mixture in which the material for the second phase is contained within and distributed through the material for the first phase; inserting the mixture into a location in a target tissue or onto a location on a target tissue; bringing the solid in powder, grain or granule form of the first phase into a sticky semi-solid state by heating the mixture before, concurrently, or after insertion; shaping the mixture to correspond to the target tissue; andallowing the material for the first phase to solidify to form a porous matrix, wherein the porous matrix has a porosity that is achieved by gaps between particles. |
