Decomposition method and decomposition apparatus for nucleic acid polymer

摘要

A method for decomposing a target nucleic acid polymer, comprising: bonding a probe nucleic acid polymer and a microparticle to form a probe nucleic acid polymer-bonded microparticle, adding a target nucleic acid polymer to the probe nucleic acid polymer contained within the probe nucleic acid polymer-bonded microparticle to form an addition microparticle, and energizing the microparticle contained within the addition microparticle into a high-energy state and then using energy transfer from this high-energy state microparticle to decompose the target nucleic acid polymer.

主权项

1. A method for decomposing a target nucleic acid polymer, comprising:
bonding a probe nucleic acid polymer and a microparticle of gold to form a probe nucleic acid polymer-bonded microparticle, hybridizing a target nucleic acid polymer to the probe nucleic acid polymer contained within the probe nucleic acid polymer-bonded microparticle to form an addition microparticle, wherein the target nucleic acid polymer is a single-stranded nucleic acid polymer; and irradiating the gold microparticle with a laser wherein the laser irradiation conditions are controlled for energizing the microparticle contained within the addition microparticle into a high-energy state and decomposing only specific sites of the target nucleic acid polymer; wherein the specific sites of the target nucleic acid polymer to be decomposed are located at a region extending no more than approximately 100 nm from a surface of the microparticle.