TREATMENT OF IL-6R RELATED DISEASES

摘要

Methods are provided for the treatment of IL-6R related diseases. More specifically, specific dose regimens and pre-filled syringes are provided for subcutaneous administration, to subjects suffering an IL-6R related disease, of immunoglobulin single variable domains that bind IL-6R.

主权项

1. A method for the treatment of an IL-6R related disease in a human subject, said method comprising the administration to a human subject suffering from the IL-6R related disease, of a polypeptide comprising, consisting essentially of, or consisting of at least one immunoglobulin single variable domain that binds IL-6R with a KD of 5×10−11 M or less and that blocks IL-6 binding to IL-6R with an IC50 of 10−9 M or less, wherein the polypeptide is administered subcutaneously at a dose of 75-300 mg every week to every month.