1-N-HYDROXYALKYL DERIVATIVES OF AMINOCLYCOSIDE ANTIBIOTICS AND THEIR USE AS ANTIBACTERIAL AGENTS

摘要

Certain 2-deoxystreptamine aminoglycoside antibiotics, substituted on the 1-amino group by an alkyl group bearing one or more hydroxy groups, are useful antibacterial agents. The 2-deoxystreptamine aminoglycoside compounds which are substituted in this manner include the kanamycins, the gentamicins, tobramycin, ribostamycin, the neomycins, and 6'-N-alkyl derivatives thereof.