| 发明名称 | Compositions and methods for transport across the blood brain barrier | ||
| 摘要 | Compositions and methods are provided including a transporter peptide derived from the loop2 domain of the neuronally-derived lynx1 protein which can be conjugated to an effector agent to form a transporter-effector complex for transport of the therapeutic effector agent to a target that is found across the blood brain barrier. | ||
| 申请公布号 | US9522193(B2) | 申请公布日期 | 2016.12.20 |
| 申请号 | US201314101196 | 申请日期 | 2013.12.09 |
| 申请人 | OPHIDION INC. | 发明人 | Walz Andreas |
| 分类号 | A61K47/48;C07K7/08;C07K14/00;A61K31/713;A61K45/06;A61K31/7088;A61K48/00 | 主分类号 | A61K47/48 |
| 代理机构 | Lewis Roca Rothgerber Christie LLP | 代理人 | Lewis Roca Rothgerber Christie LLP |
| 主权项 | 1. A composition comprising: a heterologous transporter peptide consisting of SEQ ID NO:13, wherein amino acid Xaa at position 4 of SEQ ID NO:13 is tyrosine (Y), glycine (G), or isoleucine (I), Xaa at position 7 is proline (P), and Xaa at position 10 is glycine (G). | ||
| 地址 | Bethlehem PA US | ||