| 发明名称 | Bromocriptine formulations | ||
| 摘要 | The present application describes pharmaceutical formulations of bromocriptine mesylate and methods of manufacturing and using such formulations. The formulations are useful for improving glycemic control in the treatment of type 2 diabetes. | ||
| 申请公布号 | US9522117(B2) | 申请公布日期 | 2016.12.20 |
| 申请号 | US201514920123 | 申请日期 | 2015.10.22 |
| 申请人 | VeroScience LLC | 发明人 | Cincotta Anthony H.;Bowe Craig Michael;Stearns Paul Clark;Weston Laura Jean |
| 分类号 | A61K9/20;A61K31/48;A61K31/4985;A61K9/14 | 主分类号 | A61K9/20 |
| 代理机构 | Fish & Richardson P.C. | 代理人 | Fish & Richardson P.C. |
| 主权项 | 1. A tablet comprising micronized bromocriptine mesylate and one or more excipients; wherein the micronized bromocriptine mesylate is present in an amount that provides a dose of at least about 0.8 mg of bromocriptine per tablet; wherein the micronized bromocriptine mesylate has Dv90 of less than about 10 μm; and wherein the tablet provides a dissolution profile, when tested in USP Apparatus Type 2 Paddle Method at 50 rpm in 500 mL of 0.1 N hydrochloric acid at about 37° C., wherein at least about 90% of the bromocriptine mesylate has been released at about 30 minutes. | ||
| 地址 | Tiverton RI US | ||