COMPOSITIONS AND METHODS FOR DIAGNOSIS AND PREDICTION OF SOLID ORGAN GRAFT REJECTION

摘要

Provided herein are methods, compositions, systems, and kits for diagnosing acute rejection of solid organ transplants using at least 5 genes selected from a 10-gene panel.

主权项

1. A method for aiding in the diagnosis of an acute rejection response in a subject who has received a solid organ allograft, the method comprising:
a) detecting a gene expression level for at least ten genes in a sample from the subject, wherein the at least ten genes comprise CFLAR, DUSP1, IFNGR1, ITGAX, MAPK9, NAMPT, NKTR, PSEN1, RNF130, and RYBP; and b) comparing the gene expression level to a reference expression level of the at least ten genes, wherein a statistical difference or a statistical similarity between the gene expression level and the reference expression level of at least five genes selected from the group consisting of CFLAR, DUSP1, IFNGR1, ITGAX, MAPK9, NAMPT, NKTR, PSEN1, RNF130, and RYBP, thereby aiding in the diagnosis of an acute rejection response.