发明名称 BACTERIAL EFFLUX PUMP INHIBITORS
摘要 Disclosed herein are compounds of formula I:;;and salts thereof. Also disclosed are compositions comprising of compounds of formula I and methods using compounds of formula I.
申请公布号 US2016271082(A1) 申请公布日期 2016.09.22
申请号 US201615066911 申请日期 2016.03.10
申请人 Rutgers, The State University of New Jersey 发明人 LaVoie Edmond J.;Parhi Ajit K.;Blankson Gifty A.;Kaul Malvika;Pilch Daniel S.
分类号 A61K31/166;C07C233/78;A61K45/06 主分类号 A61K31/166
代理机构 代理人
主权项 1. A compound of formula I: wherein: R1 is (C3-C8)alkyl substituted with two or more groups selected from —NRb1Rc1, —NHNH2, —C(═NRa1)(NRb1Rc1), —NRa1C(═NRa1)(Rd1) and —NRa1C(—NRa1)(NRb1Rc1); R2 is hydrogen or (C1-C3)alkyl; each R3 is independently hydrogen, halo or (C1-C4)alkyl; R4 is hydrogen, halo, (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxy, (C1-C4)haloalkoxy, aryl or heteroaryl wherein the aryl or heteroaryl is optionally substituted with one or more groups independently selected from halo, (C1-C4)alkyl, (C1-C4)haloalkyl, (C1-C4)alkoxy and (C1-C4)haloalkoxy; R5 is hydrogen, halo, (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxy, (C1-C4)haloalkoxy, aryl or heteroaryl wherein the aryl or heteroaryl is optionally substituted with one or more groups independently selected from halo, (C1-C4)alkyl, (C1-C4)haloalkyl, (C1-C4)alkoxy and (C1-C4)haloalkoxy; R6 is hydrogen, halo, (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxy, (C1-C4)haloalkoxy, aryl or heteroaryl wherein the aryl or heteroaryl is optionally substituted with one or more groups independently selected from halo, (C1-C4)alkyl, (C1-C4)haloalkyl, (C1-C4)alkoxy and (C1-C4)haloalkoxy; R7 is hydrogen, halo, (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxy, (C1-C4)haloalkoxy, aryl or heteroaryl wherein the aryl or heteroaryl is optionally substituted with one or more groups independently selected from halo, (C1-C4)alkyl, (C1-C4)haloalkyl, (C1-C4)alkoxy and (C1-C4)haloalkoxy; R8 is hydrogen, halo, (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxy, (C1-C4)haloalkoxy, aryl or heteroaryl wherein the aryl or heteroaryl is optionally substituted with one or more groups independently selected from halo, (C1-C4)alkyl, (C1-C4)haloalkyl, (C1-C4)alkoxy and (C1-C4)haloalkoxy; each Ra1 is independently hydrogen or (C1-C4)alkyl; each Rb1 and Rc1 is independently hydrogen or (C1-C4)alkyl; Rd1 is (C1-C3)alkyl and n is 0 or 1; or a salt thereof.
地址 New Brunswick NJ US