IONIC GELATION ON SOLIDS

摘要

The invention relates to a method for ionic gelation on solids for encapsulating water-insoluble solids. The method uses negatively charged macromolecules and soluble salts of polyvalent cations as shell-forming materials having a high adsorption on the surface of the solid when subjected to thermal treatment. The shell-forming material represents at least 10% of the weight of the dry microcapsule obtained. The obtained microcapsule can be redispersed in water and treated by altering the environment thereof in order to be used as an encapsulating medium for water-soluble compounds and they can also be used as active ingredients and/or excipients in the production of pharmaceutical or nutraceutical compositions.

主权项

1. A process for encapsulating a water-insoluble solid by means of ionic gelation, which consists of:
a) elaborating a solution of macromolecules that contain negative charges in their structure; b) elaborating an aqueous solution of the water-insoluble solid; c) adding the solution of negatively charged macromolecules from step a) to the aqueous suspension from step b) under stirring and thermal treatment conditions; d) adding a source of polyvalent cations to the aqueous suspension obtained in step c) until a shell that covers the insoluble solid is formed; e) increasing the temperature of the system to room temperature or higher.