发明名称 |
Z-omega-substituted thio-2-(2,2-dimethylcyclopropanecarboxamido)-2-alkenoic acids, a process for preparing and an antibacterial composition containing the same. |
摘要 |
<p>Novel chemical compounds and a process for preparing them are provided. These compounds selectively inhibit the metabolism of dipeptidase (E.C.3.4.13.11) and therefore are useful in combination with antibacterial products. These chemical compounds are Z-2-(2,2-dimethylcyclopropanecarboxamido)- omega -pyridylthio-2-alkenoic acids (and related arylthio and heterocyclylthio analogs) of the general formula: <CHEM> wherein n is an integer from 3-5, Y is pyridyl, pyrimidinyl, tetrazolyl, imidazolyl, thiadiazolyl, thiazolinyl, or phenyl, optionally having 1 or 2 substituents which are hydroxyl, oxo, carboxyl, or methyl; and the loweralkyl (C1-6) esters and pharmaceutically acceptable salts thereof.</p> |
申请公布号 |
EP0049389(A1) |
申请公布日期 |
1982.04.14 |
申请号 |
EP19810107303 |
申请日期 |
1981.09.16 |
申请人 |
MERCK & CO. INC. |
发明人 |
ASHTON, WALLACE T.;BARASH, LOUIS;BROWN, JEANNETTE E.;GRAHAM, DONALD W. |
分类号 |
A61K31/19;A61K31/195;A61K31/397;A61K31/40;A61K31/41;A61K31/433;A61K31/44;A61K31/4402;A61K31/4406;A61K31/4409;A61K31/505;A61P31/04;A61P43/00;C07C67/00;C07C313/00;C07C323/59;C07C323/62;C07D213/70;C07D213/80;C07D233/84;C07D239/56;C07D257/04;C07D277/20;C07D277/36;C07D285/04;C07D477/00;C07D477/10;C07D477/20;C12N9/99;(IPC1-7):07D213/70;07D487/04;61K31/395;07D213/80;07C103/46;07D277/36;07C149/40;07D239/56;07D257/04 |
主分类号 |
A61K31/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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