| 摘要 |
The invention relates to a method of solubilizing a pharmaceutical active ingredient, to the use of this method of making a pharmaceutical composition in the form of a dermal and/or transdermal preparation, to a pharmaceutical composition containing this compound, and to at least one pharmaceutical active ingredient, an aerosol dispenser with such a composition, and to a method of making such a composition. |
| 主权项 |
1. A method of solubilizing a pharmaceutical active ingredient in an aqueous and/or organic solvent, the solvent being a compound of Formula I or a mixture of different such compounds, or a mixture of the compound or of the mixture of the different such compounds with an additional solvent, comprising the step of solubilizing the active ingredient in the compound or in the solvent containing the compound,wherein R1 to R5 are independently from each other, identically or different, selected from the group consisting of —H, —OH, methyl, ethyl, propyl, isopropyl, isopropenyl, and alkoxy, wherein R6 is selected from —O—R7 and —CO—R7, with R7 being selected from —H, C1-C3-alkyl, C6-aryl and C7-C10-aralkyl, substituted or not substituted, and wherein the aromatic ring of the illustration of Formula I may be replaced by C6-cycloalkyl, saturated or mono-unsaturated or di-unsaturated, at an arbitrary position of the cycloalkyl ring. |
