| 发明名称 |
Stable preservative-free mydriatic and anti-inflammatory solutions for injection |
| 摘要 |
The present invention relates to stable, preservative- and antioxidant-free liquid formulations of phenylephrine and ketorolac for injection. |
| 申请公布号 |
US9486406(B2) |
申请公布日期 |
2016.11.08 |
| 申请号 |
US201514721151 |
申请日期 |
2015.05.26 |
| 申请人 |
Omeros Corporation |
发明人 |
Demopulos Gregory A.;Shen Hui-rong;Tedford Clark E. |
| 分类号 |
A61K31/135;A61K31/40;A61K31/19;A61K9/00;A61K31/137;A61K31/407;A61K31/138 |
主分类号 |
A61K31/135 |
| 代理机构 |
|
代理人 |
Kelbon Marcia S. |
| 主权项 |
1. A sterile liquid pharmaceutical formulation comprising phenylephrine, ketorolac, and a buffer system that is injected into and an intraocular irrigation carrier, wherein after injection the phenylephrine is included at a concentration of from 30 to 720 μM and the ketorolac is included at a concentration of from 10 to 270 μM, and wherein the formulation is stable for a period of at least 24 months when stored at a temperature of from 5+/−3° C. to 25+/−2° C. |
| 地址 |
Seattle WA US |
