Truncated tau proteins

摘要

Described are novel N- and C-terminally double truncated tau molecules, (“type IA, IB, IIA and IIB tau molecules”) as well as methods for providing these molecules, both from recombinant and biological sources. Moreover, screening methods using these molecules in connection with Alzheimer's diagnosis and therapy are provided.

主权项

1. An isolated recombinant cell genetically modified with a vector, wherein the vector comprises a cDNA encoding a fragment of the human tau43 molecule of SEQ ID NO:35 functionally linked to a promoter, and wherein the amino acid sequence of the fragment of tau43 consists of SEQ ID NO:13, SEQ ID NO:14, or a subsequence of SEQ ID NO:35 that comprises at least SEQ ID NO:11 or SEQ ID NO:12, does not extend N-terminally beyond amino acid residue 68 of SEQ ID NO:35, and does not extend C-terminally into the last 40 amino acids of SEQ ID NO:35.