| 发明名称 | Anti-EGFR antibodies and antibody drug conjugates | ||
| 摘要 | The invention relates to anti-epidermal growth factor (EGFR) antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs. | ||
| 申请公布号 | US9493568(B2) | 申请公布日期 | 2016.11.15 |
| 申请号 | US201514664453 | 申请日期 | 2015.03.20 |
| 申请人 | AbbVie Inc. | 发明人 | Reilly Edward B.;Phillips Andrew C.;Benatuil Lorenzo;Hsieh Chung-Ming;Perez Jennifer |
| 分类号 | C07K16/28;A61K47/48;C07K14/00;A61K39/00 | 主分类号 | C07K16/28 |
| 代理机构 | McCarter & English, LLP | 代理人 | McCarter & English, LLP ;Cowles Christian H.;Fiala Kevin A. |
| 主权项 | 1. An anti-human epidermal growth factor receptor (anti-hEGFR) antibody comprising a heavy chain CDR3 domain comprising the amino acid sequence set forth in SEQ ID NO: 12, a heavy chain CDR2 domain comprising the amino acid sequence set forth in SEQ ID NO: 11, and a heavy chain CDR1 domain comprising the amino acid sequence set forth in SEQ ID NO: 10; and a light chain CDR3 domain comprising the amino acid sequence set forth in SEQ ID NO: 8, a light chain CDR2 domain comprising the amino acid sequence set forth in SEQ ID NO: 7, and a light chain CDR1 domain comprising the amino acid sequence set forth in SEQ ID NO: 6, wherein the antibody is an IgG isotype. | ||
| 地址 | North Chicago IL US | ||