发明名称 |
FREMGANGSMAADE TIL FREMSTILLING AF ET B30-THREONIN-INSULIN |
摘要 |
<p>A process for preparing a B30-threonine-insulin is described which comprises reacting a des-B30-insulin with an excess amount of a threonine derivative represented by the formula Thr(R<1>)(R<2>) wherein Thr is L-threonine residue, R<1> is hydrogen or a hydroxy-protecting group; and R<2> is a carboxyl-protecting group, in the presence of an enzyme specifically acting on the basic-amino-acid carbonyl in peptide linkages.</p> |
申请公布号 |
DK146482(B) |
申请公布日期 |
1983.10.17 |
申请号 |
DK19800001556 |
申请日期 |
1980.04.11 |
申请人 |
SHIONOGI & CO. LTD. |
发明人 |
KAZUYUKI MORIHARA;TATSUSHI OKA;HIROSHIGE TSUZUKI;MASAMI SOEJIMA;TAKEHARU MASAKI |
分类号 |
C07K14/62;(IPC1-7):C12P21/02;C07C103/52 |
主分类号 |
C07K14/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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