摘要 |
Carbacycline derivatives having the formula I wherein R1 is the residue CH2OH or <IMAGE> -C-OR2, R2 representing a hydrogen atom, an alkyl, cycloalkyl, aryl, <IMAGE>CH2 -C-aryl residue or a heterocyclic residue, or R1 is the residue <IMAGE>-C-NHR3, R3 representing an alkanoyl or alkanesulfonyl residue containing each 1 to 10 atoms of carbon or the residue R2 or R1 is the residue <IMAGE>wherein m is 1 or 2. X is an oxygen atom or CH2 group, A is a trans -CH=CH- or -C=C- group, W is a free or modified hydrocymethylene group wherein the OH group may be in the position alpha or beta , n represents the integer 1, 2 or 3, D is a straight chain alkylene group with 1 to 3 atoms of carbon, E represents a -C=C- bond or a -CR6=CR7 group, R6 and R7 being different and representing a hydrogen atom or an alkyl group with 1 to 5 atoms of carbon or a hydrogen atom or an a halogen atom, preferably chlorine, R4 represents an alkyl, cycloalkyl group or an optionally substituted aryl group or a heterocyclic group, R5 represents a free or modified hydroxy group. When R2 represents a hydrogen atom, the salts of compounds with pharmaceutically acceptable bases are also involved. The compounds are used as hypotensive agents. |