发明名称 |
Method for administering scopolamine transdermally |
摘要 |
Method and therapeutic system in the form of a bandage that administer scopolamine base transdermally in an initial pulse of 10 to 200 mu g/cm2 of skin that quickly brings the concentration of scopolamine in the plasma to a level at which emesis and nausea are inhibited without intolerable side effects, followed by a substantially constant dosage in the range of 0.3 to 15 mu g/hr that holds said level. The bandage is a four-layer laminate of, from the top: a protective backing; a gelled, mineral oil-polyisobutene-scopolamine reservoir lamina that is the source of the constant dosage; a microporous membrane that controls the constant dosage rate; and a gelled, mineral oil-polyisobutene-scopolamine adhesive layer that is the source of the pulse dose and the means by which the bandage is attached to the skin.
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申请公布号 |
US4436741(A) |
申请公布日期 |
1984.03.13 |
申请号 |
US19830474754 |
申请日期 |
1983.03.14 |
申请人 |
ALZA CORPORATION |
发明人 |
URQUHART, JOHN;CHANDRASEKARAN, SANTOSH K.;SHAW, JANE E. |
分类号 |
A61F13/00;A61F13/15;A61K9/70;A61K31/46;A61M37/00;(IPC1-7):A61K31/44 |
主分类号 |
A61F13/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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