发明名称 |
Imide-based modulators of proteolysis and associated methods of use |
摘要 |
The description relates to imide-based compounds, including bifunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the description provides compounds, which contain on one end a ligand which binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. Compounds can be synthesized that exhibit a broad range of pharmacological activities consistent with the degradation/inhibition of targeted polypeptides of nearly any type. |
申请公布号 |
AU2015247817(A1) |
申请公布日期 |
2016.10.27 |
申请号 |
AU20150247817 |
申请日期 |
2015.04.14 |
申请人 |
Arvinas, Inc. |
发明人 |
Crews, Craig;Crew, Andrew P.;Dong, Hanqing;Wang, Jing;Qian, Yimin;Siu, Kam;Jin, Meizhong |
分类号 |
C07D401/14;A61K47/48;C12N9/12 |
主分类号 |
C07D401/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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