PET MONITORING OF Aβ-DIRECTED IMMUNOTHERAPY

摘要

PROBLEM TO BE SOLVED: To provide PET monitoring of Aβ-directed immunotherapy.SOLUTION: The method of the invention comprises administration of a PET ligand represented by the following formula that binds to amyloid deposits and detection of the PET ligand in the brain so as to provide an indication of the level and/or distribution of amyloid deposits.EFFECT: The data in the present application show that a statistically significant reduction in amyloid deposits occurs early and consistently among patients following initiation of treatment before statistically significant effects of most if not all other markers are detectable. In consequence, the present methods allow early detection of whether a patient is responding to the Aβ-directed immunotherapy and if necessary adjustment of the immunotherapy regime.SELECTED DRAWING: None