| 摘要 |
NEW MATERIAL:A prostaglandin (PG for short) D analog compound shown by the formula I {[A] is group shown by the formula II, III (double bond between C9-C10 is Z, etc.; X is ethylene, or cis-vinylene; C13-C14-C15 is group shown by the formula IV (double bond in C13-C14 is E), etc.; R is -CO-CR<3>=CR<4>R<5>(R<3>, R<4>, and R<5> are H, or 1-4C alkyl), etc.; R<1> is single bond, or 1-5C alkylene; R<2> is 1-8C alkyl, etc.}, or its cyclodextrin inclusion compound. EXAMPLE:1-O-(3,3-Dimethylacryloyl)-PGD2 alcohol. USE:A strong antitumor agent, having extremely low toxicity. PREPARATION:For example, a compound shown by the formula V (R<b> is H, etc.) is reacted using an aqueous solution of an acid such as HCl, etc. in an inert organic solvent such as methylene chloride, etc. at the reflux temperature of the solvent, to prepared the compound shown by the formula I (with the proviso that R=R<b>).
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