Calcium phosphate material

摘要

The invention relates to porous granular calcium phosphate osteoinductive materials, particularly materials useful in body tissue repair, principally bone repair and bone replacement, and also to the use of such materials and to a method of making such materials. Exemplary materials comprise discrete porous granules each containing crystals of at least one calcium phosphate, wherein (i) at least 90% of said crystals of the granules have a crystal size in the range 10-100 nm, (ii) at least 90% of the pores in the granules have a pore size in the range 10-500 nm, (iii) the average pore size of the pores having pore size in the range 10-500 nm in the granules is in the range 30-90 nm, (iv) the total volume porosity of the granules is at least 50%, and (v) the surface area of the granules is in the range 10-70 m2/g.

主权项

1. A porous granular calcium phosphate material, comprising discrete porous granules each containing crystals of at least one calcium phosphate, wherein
(i) at least 90% of said crystals of the granules have a crystal size in the range 1.0-100 nm, where the crystal size is the longest dimension of the crystal as seen in a cross-sectional SEM, (ii) at least 90% of the pores in the granules have a pore size in the range 10-500 nm, wherein the pore size is the longest dimension of the pore as seen in a cross-sectional SEM, (iii)the average pore size of the pores having pore size in the range 10-500 nm in the granules is in the range 30-90 nm, as measured by mercury intrusion porosimetry, (iv) the total volume porosity of the granules, measured using Archimedes's principle, is at least 50% , and (v) the surface area of the granules, measured by the BET method, is in the range 1 0-70 m2/g, wherein at least 90% of said crystals have at least one dimension of not more than 50 nm as seen in a cross-sectional SEM, and wherein said crystals of said granules are in a substantially unsintered stat.