PROCESS FOR PREPARING 2-ALKYL-7-ACYLAMINO-2-(OR 3)-CEPHEM-4-CARBONIC ACIDS

摘要

Cephemcarboxylic acids I [R1 = H, OAc, 1-methyltetrazol-5ylthio, 2- methyl-1,3,4-thiadiazol-5-ylthio; R2 = Ph, 4-HOC6H4, 3,4-Cl(HO)C6H3 were converted to N-acylation products II [R1 = alkyl; R2 = acylamino; X = S . 2-methyl-7-amino-3-cephem-4-carbonic acid was stirred with diglycolic anhydride in Me2CO at room temperature to give II.