Homologues of aprotinin with other amino acids in position 15 instead of lysine, process for their preparation and their use as medicaments

摘要

The invention relates to homologues of aprotinin in which the lysine residue in the active centre of the inhibitor aprotinin in position 15 is exchanged for one of the residues of the amino acids glycine, L-alanine, L-valine, L-leucine, L-isoleucine, L-methionine, L-arginine, L- alpha -aminobutyric acid, L-norvaline, L-norleucine, dehydroalanine and L-homoserine, a process for their preparation and their use as medicaments.