| 摘要 |
<p>NEW MATERIAL:A compound shown by the formula I [A is H, (1-lower alkyl-5- tetrazolyl)thio, or substituted-1-pyridinio; B is H, or anion] or its salt. EXAMPLE:7-[ alpha-( 2-Amino-4-thiazolyl)-alpha-(thiocarbamoylmethoxyimino)acetamido ]- 3-methyl-DELTA<3>-cephem-4-carboxylic acid. USE:An antibacterial agent. Having improved effect especially on Gram-positive bacteria. PREPARATION:For example, a substituted oxyiminothiazolyacetic acid derivative shown by the formula II (R<2> is H, or amino protecting group) is reacted with a 7-amino-3-cephem derivative shown by the formula III (R<3> is as shown for R<2>; R<4> is H, or carboxy-protecting group) in a solvent such as dioxane, etc. by the use of a condensation agent such as N,N'-dicyclohexylcarbodiimide, etc., and optionally deprotected, to give a compound shown by the formula I .</p> |
