AMINO ACID DERIVATIVE

摘要

NEW MATERIAL:The compound of formula I [R<1> is (substituted) alkyl, cycloalkyl, aryl etc.; R<2> and R<10> are H or carboxyl-protecting group; R<3> is H, (substituted) alkyl, alkenyl, etc.; R<4>-R<9> are H, (substituted) alkyl, cycloalkyl, etc.; Z is single bond, methylene, ethylene, etc.; Y is group of formula II (n is 0, 1 or 2)] or its pharmacologically permissible salt. EXAMPLE:N-[ N-[1( S )-ethoxycarbonyl-3-phenylpropyl]-L-alanyl ]-6(R) or 6( S )- phenyltetrahydro-2H-1,4-thiazine-3(R)-carboxylic acid methyl ester. USE:A hypotensor and its important synthetic intermediate. PREPARATION:The compound of formula I can be prepared by the condensation of the compound of formula III with the compound of formula IV.