COVALENTLY MODIFIED BACTERIAL POLYSACCHARIDES, STABLE COVALENT COMPOSITE BODY BY DIVALENT SPACER OF SAME AND IMMUNOGENIC PROTEIN, MANUFACTURE THEREOF AND DETERMINATION OF COVALENT BOND

摘要

Covalently modified bacterial polysaccharides and proteins; covalent conjugates of such polysaccharides linked by a bigeneric spacer, which permits proof of covalency and facilitates purification of conjugated materials, with immunogenic bacterial membrane or other proteins, which conjugates are useful components of bacterial vaccines; and methods of preparing such polysaccharides, proteins and conjugates and of confirming the covalency of the linkage between polysaccharides and proteins.