| 摘要 |
NEW MATERIAL:The 1-benzoxepin-2-one derivative of formula I (R is H, 1-3C alkoxy or halogen). EXAMPLE:5-Phenyl-2-oxo-2,3,4,5-tetrahydro-1-benzoxepine. USE:Useful as a synthetic intermediate of various medicinal drugs having cerebral function improving action and active to circulatory system, central nervous system, digestive system, etc. For example, a diallylbutyric acid derivative exhibiting the above activities at a low dose and also having the lipid peroxide suppressing effect, can be synthesized by dissolving the compound of formula I in a solvent, adding excess N-methylpiperazine to the solution and heating and refluxing the mixture. PREPARATION:The compound of formula I can be prepared by reacting gamma- phenyl-gamma-butyrolactone with the phenol derivative of formula II in the presence of a base, and subjecting the resultant compound of formula III to the coordination and dehydrative cyclization under acidic condition. |
