Pyrimidinones as factor XIa inhibitors

摘要

The present invention provides compounds of Formula (I):;
or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

主权项

1. A compound of Formula (VII):or a stereoisomer, a tautomer, a pharmaceutically acceptable salt thereof, wherein:
ring A is independently selected from ring B is independently selected from R1 is independently selected from H and C1-4 alkyl; R10 is independently selected from H, F, Cl, CF3, CHF2, and COOH; R3c is independently selected from H, CHF2, CD3, CH3, and R8b is independently selected from H and F; and R8c is independently selected from H, F, Cl, CH3, and OCH3.