MONO-ETHERS OF ISOHEXIDES AND PROCESS FOR MAKING THE SAME

摘要

A method of making a mono-ether of an isohexide and art assemblage of novel. Song-chain isohexide mono-ethers are described. In particular, the method involves reacting an isohexide stereoisomer with a Bronsted base and an alkyl species. The resultant mono-ethers can serve as attractive antecedents or chemical scaffolds for making a derivative compound, such as various amphiphiles with potential uses as surfactants, dispersants, and lubricants, among others.

主权项

1. A method of making a mono-ether of an isohexide, comprising: reacting an isohexide with a Brønsted base and an alkyl species in a reaction system, said isohexide and a conjugate acid of said Brønsted base each having an acid disassociation constant, pKa Wherein an absolute value of the difference (ΔpKa=pKa Brønsted base−pKa isohexide —OH) between said pKa values of said isohexide stereoisomer and said conjugate acid of said Brønsted base is at least 0.