发明名称 |
METHOD OF DESIGNING SIRNAS FOR GENE SILENCING |
摘要 |
The present invention provides a method for identifying siRNA target motifs in a transcript using a position-specific score matrix approach. The invention also provides a method for identifying off-target genes of an siRNA using a position-specific score matrix approach. The invention further provides a method for designing siRNAs with higher silencing efficacy and specificity. The invention also provides a library of siRNAs comprising siRNAs with high silencing efficacy and specificity. |
申请公布号 |
CA2543954(C) |
申请公布日期 |
2016.11.08 |
申请号 |
CA20042543954 |
申请日期 |
2004.10.27 |
申请人 |
ROSETTA INPHARMATICS LLC |
发明人 |
JACKSON, AIMEE L.;BARTZ, STEVEN R.;BURCHARD, JULJA;LINSLEY, PETER S.;GE, WEI;CAVET, GUY L. |
分类号 |
C40B40/06;C07H21/02;C12N;C12N15/11;C12N15/113;C12Q1/68;C40B30/02;G06F19/20;G06F19/22 |
主分类号 |
C40B40/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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