| 摘要 |
Oxazole and isoxazole derivatives of the formula <IMAGE> I wherein A is C1-6-alkylene, Het is a 2-R-oxazol-5-yl, 5-R-oxazol-2-yl, 4-R-oxazol-2-yl, 2-R-oxazol-4-yl, 3-R-isoxazol-5-yl or 5-R-isoxazol-3-yl group which is optionally substituted on the heterocyclic ring by a C1-6-alkyl group, R is phenyl or thienyl monosubstituted or disubstituted by halogen, trifluoromethyl or C1-6-alkylthio, R1 and R2 each is a C1-6-alkyl group and R3 is a hydroxy or C1-6-alkoxy group or a group of the formula -NR4R5 in which R4 and R5 each is a hydrogen atom or a C1-6-alkyl group or R4 and R5 together with the nitrogen atom to which they are attached is a 5-membered or 6-membered saturated heteromonocyclic ring which may contain an oxygen or sulphur atom or an additional nitrogen atom, and pharmaceutically acceptable salts of the compounds of formula I in which R3 is a hydroxy group with bases, have anti-arthritic activity. |
