| 摘要 |
A compound of formula I <CHEM> wherein R1 is C1-4alkyl, C3-4alkenyl or (C3-5cycloalkyl)-methyl, R2 is C1-4alkyl, [hydroxy- or (C1-4alkoxy)-substituted C1-3alkyl]-methyl, (C3-5cycloalkyl)-methyl, tetrahydrofuran-2-yl-methyl or 1,3-dioxolan-2-yl-methyl, R3 and R4 are each hydrogen, hydroxymethyl, methoxymethyl or N,N-dimethylcarbamoyloxymethyl, R5 is hydroxy or methoxy, R6 is hydrogen, hydroxy, methoxy or halogen and R7 is in the 2- or 3-position and is hydroxy, methoxy or halogen, or together with R5 is 3,4-methylendioxy, or together with R6 is 2,3-methylenedioxy and their physiologically-hydrolysable and -acceptable esters are useful in the treatment (symptomatic and prophylactic) of obstructive or inflammatory airways disease, in particular asthma, and disease characterised by or having an aetiology comprising morbid eosinophil accumulation or activation, e.g. hypereosinophilia.
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