| 摘要 |
1. Claims for the contracting States BE, CH, DE, FR, GB, IT, LI, LU, NL, SE Cis-platinum complexes of the general formula see diagramm : EP0262498,P18,F5 wherein R1 denotes hydrogen, a hydroxyl group or a C2 -C6 - alkanoyloxy group, R2 denotes hydrogen or a halogen atom, R3 denotes hydrogen or a C1 -C6 -alkyl group, R4 denotes a hydroxyl group or a C2 -C6 -alkanoyloxy group, R5 denotes hydrogen or a halogen atom and R6 denotes hydrogen or a halogen atom, Alk represents a C2 -C10 -alkylene chain, where 4 adjacent CH2 groups may furthermore be replaced by a 1,4-phenylene ring, see diagramm : EP0262498,P18,F6 denotes the group see diagramm : EP0262498,P18,F7 see diagramm : EP0262498,P18,F8 or see diagramm : EP0262498,P19,F1 and R7 is a hydrogen atom, a C1 -C6 -alkyl group or a phenyl radical and X represents one equivalent of a physiologically tolerated anion. 1. Claims for the contracting States AT, ES, GR Process for the preparation of cis-platinum complexes of the general formula see diagramm : EP0262498,P20,F1 wherein R1 denotes hydrogen, a hydroxyl group or a C2 -C6 -alkanoyloxy group, R2 denotes hydrogen or a halogen atom, R3 denotes hydrogen or a C1 -C6 -alkyl group, R4 denotes a hydroxyl group or a C2 -C6 -alkanoyloxy group, R5 denotes hydrogen or a halogen atom and R6 denotes hydrogen or a halogen atom, Alk represents a C2 -C10 -alkylene chain, where 4 adjacent CH2 groups may furthermore be replaced by a 1,4-phenylene ring, see diagramm : EP0262498,P20,F2 denotes the group see diagramm : EP0262498,P20,F3 see diagramm : EP0262498,P20,F4 or see diagramm : EP0262498,P20,F5 and R7 is a hydrogen atom, a C1 -C6 -alkyl group or a phenyl radical and X represents one equivalent of a physiologically tolerated anion, characterised in that a tetrahaloplatinum (II) acid, a tetrahaloplatinum (II) complex salt having two monovalent cations or one divalent cation or a platinum(II) halide is reacted with a compound of the formula see diagramm : EP0262498,P20,F6 or a salt of the compound II, wherein the radicals R1 , R2 , R3 , R4 , R5 and R6 and the groups Alk and A-B have the stated meanings, and, if required, the radical X or the radicals X in a resulting compound of the formula I is or are exchanged for other physiologically tolerated anions. |
