| 摘要 |
Vasopressin antagonists which have a tripeptide side chain comprised of three basic amino acids, such as arginine, lysine or ornithine, having the formula: <CHEM> demonstrate potent V1 and V2-antagonist activity. A species of the invention, which is prepared by conventional peptide sequencing, is [1-( beta -mercapto- beta , beta -cyclopentamethylenepropionic acid)-2-(O-ethyl)-D-tyrosine-4-valine-7-arginine-8-arginine-9-arginine ]-vasopres sin. |
