| 摘要 |
PURPOSE:To obtain the titled pharmaceutical containing a cembrane type diterpene compound as an active ingredient, having strong affinity to inflammatory cell, inhibiting aggravation of inflammation, acting to chronic rheumatism or the like as well as mast cell and effective to colitis ulcerosa or the like. CONSTITUTION:A cembrane type diterpene compound expressed by formula I or formula II (R is H or acyl group) is contained. The above-mentioned compound expressed by formula I or formula II is obtained from a coelenterate, Sarcophyton glaucum belonging to Gorgonacea. Namely the compound is separated from a lipid fraction of extract of the Sarcophyton glaucum by a silica gel chromatography. When extracted, the coelenterate is preferably dehydrated and finely cut so that the consistency of the surface is lost. And during the extraction treatment the coelenterate is preferably treated so as to minimize the contact area with air or under an inert gas atmosphere. |
