| 摘要 |
1. Claims (for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE) Process for the preparation of suspensions of uniformly shaped crystals having a substantially homogeneous size distribution, in particular prisms about 10 mu m in size, of one or more insulin derivatives of the formula I see diagramm : EP0133285,P10,F1 in which R**1 denotes H or H-Phe, R**30 represents the residue of a neutral, genetically encodable L-amino acid and R**31 represents a physiologically tolerated organic group which is basic in character and has up to 50 C atoms, and in whose structure 0 to 3 alpha-amino acids and involved, and whose terminal carboxyl group, which is present where appropriate, can be in the free form, or in the form of an ester group, an amide group, a lactone or reduced to CH2 OH, having an isoelectric point between 5.8 and 8.5, characterized in that the crystallization is carried out in an aqueous medium in the neighbourhood of the isoelectric point of the derivative(s) in the presence of glycerol as tonicizing agent and at least one phenol. 1. Claims (for the Contracting State AT) Process for the preparation of suspensions of uniformly shaped crystals having a substantially homogeneous size distribution, in particular prisms about 10 mu m in size, of one or more insulin derivatives of the formula I see diagramm : EP0133285,P11,F1 in which R**1 denotes H or H-Phe, R**30 represents the residue of a neutral, genetically endocable L-amino acid and R**31 represents a physiologically tolerated organic group which is basic in character and has up to 50 C atoms, and in whose structure 0 to 3 alpha-amino acids are involved, and whose terminal carboxyl group, which is present where appropriate, can be in the free form, or in the form of an ester group, an amide group, a lactone or reduced to CH2 OH, having an isoelectric point between 5.8 and 8.5, characterized in that the crystallization is carried out in an aqueous medium in the neighbourhood of the isoelectric point of the derivative(s) in the presence of glycerol as tonicizing agent and at least one phenol. |
