PROCESS FOR THE PURIFICATION OF γ-CARBOXYLATED POLYPEPTIDES

摘要

The present invention relates to a process for the purification of a γ-carboxylated polypeptide such as Factor VII, comprising subjecting a liquid containing said γ-carboxylated polypeptide to the steps of affinity chromatography and multimodal anion exchange chromatography. Also provided is a manufacturing process for producing a γ-carboxylated polypeptide of interest.