| 发明名称 |
NEOCARZINOSTATIN DERIVATIVES AND METHOD OF PRODUCING THE SAME |
| 摘要 |
<p>Substantially pure neocarzinostatin anticancer agents have the formula (A): (SMA)-(NCS)-(SMA) (A) wherein (NCS) is a divalent neocarzinostatin residue and (SMA) comprises the monovalent residue of a partially half-esterified styrene-maleic acid copolymer having a weight-average molecular weight of from 800 to 2,500, said (NCS) residue being bonded to said (SMA) residues via amide linkages formed between primary amino groups of the neocarzinostatin molecule and carbonyl groups of the partially half-esterified styrene-maleic acid copolymer.</p> |
| 申请公布号 |
EP0136791(B1) |
申请公布日期 |
1989.03.08 |
| 申请号 |
EP19840305413 |
申请日期 |
1984.08.08 |
| 申请人 |
KURARAY CO., LTD.;YAMANOUCHI PHARMACEUTICAL CO. LTD.;KABUSHIKI KAISHA KAYAKU (ALSO TRADING AS KAYAKU ANTIBIOTICS RESEARCH CO. LTD.);MAEDA, HIROSHI |
发明人 |
MAEDA, HIROSHI;KANAMARU, RYUNOSUKE;ISHIDA, NAKAO;YOSHITAKE, TOSHIHIKO;UEDA, MINORU |
| 分类号 |
C08F8/00;A61K31/00;A61K31/785;A61K38/00;A61P35/00;C07K1/113;C07K14/00;C07K14/195;C07K14/41;C07K17/08;C08F8/32;C08F212/08;C08F222/02;(IPC1-7):C07K15/00;C08F222/08;A61K37/02 |
主分类号 |
C08F8/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
