| 摘要 |
Enantioselective process for preparation of diols of formula (I), wherein Ar is selected from aryl, heteroaryl, substituted aryl and substituted heteroaryl and R is a carboxyl group, an esterified carboxyl or a group capable of being converted to said carboxyl or esterified carboxyl; the process comprising reacting a compound of formula (III): Ar-H C=C H R, with no more than 20 mole percent based on said compound of formula (III) of osmium tetroxide in the presence of an optically-active nitrogen-containing compound and an oxidant. Compounds of formula (I) are useful as intermediates in preparation of biologically active compounds and in particular the pharmaceutical Diltiazem. |
