摘要 |
A bioerodible controlled drug release implant is produced which contains a suitable pharmaceutically active compound dispersed uniformly throughout a polymeric matrix. An implant is prepared by dissolving a suitable bioerodible polymer in an organic solvent followed by the addition of a predetermined amount of a pharmaceutical preparation. The solution is mixed until the polymer and drug are fully dissolved. The solution is then evaporated to dryness where the dry polymer/drug composition is reduced to a granular composition which is then formed by compression molding into the desired shaped. The pharmaceutical preparation may be a drug in pure form or a solution of a drug dissolved in a suitable solvent. In the event the solution of the drug is immiscible with the polymer solution a suitable dispersing agent is included in the drug solution to disperse the drug with the polymer. Devices formed by the method are suitable for controlled drug release devices, bone or other prosthesis and the like. |