发明名称 |
A PROCESS FOR THE PREPARATION OF ANTIBODIES BY GENETIC ENGINEERING |
摘要 |
Functional antibody fragments can be produced in bacteria by coupling each of the genes for the individual chains to signal sequences which bring about the transport of the prepeptides through the cytoplasmic membrane, expressing the gene structures in a bacterium, and isolating the functional protein from the periplasmic space or the medium. The functional protein is advantageously isolated by affinity chromatography on an adsorbent which is loaded with the hapten or antigen, and elution with a solution of the hapten or antigen. |
申请公布号 |
AU2761788(A) |
申请公布日期 |
1989.07.06 |
申请号 |
AU19880027617 |
申请日期 |
1988.12.30 |
申请人 |
DR. ANDREAS PLUCKTHUN |
发明人 |
DR. ANDREAS PLUCKTHUN;ARNE SKERRA |
分类号 |
C12N1/21;C07H21/04;C07K14/005;C07K14/195;C07K16/00;C07K19/00;C12N15/09;C12N15/62;C12P21/00;C12P21/02;C12R1/19 |
主分类号 |
C12N1/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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