发明名称 |
COMPOSITIONS COMPRISING AAV EXPRESSING DUAL ANTIBODY CONSTRUCTS AND USES THEREOF |
摘要 |
A recombinant adeno-associated virus (AAV) having an AAV capsid and packaged therein a heterologous nucleic acid which expresses two functional antibody constructs in a cell is described. Also described are antibodies comprising a heavy chain and alight chain from a heterologous antibody. In one embodiment, the antibodies are co-expressed from a vector containing: a first expression cassette which encodes at least a first open reading frame (ORF) for a first immunoglobulin under the control of regulatory control sequences which direct expression thereof; and a second expression cassette which comprises a second ORF, a linker, and a third ORF under the control of regulatory control sequences which direct expression thereof, wherein the second and third ORF encode a second and third immunoglobulin construct. The vector co-expressing these two antibody constructs is in one embodiment an AAV, in which the 5′ and 3′ ITRs flank the expression cassettes and regulatory sequences. |
申请公布号 |
SG11201609207S(A) |
申请公布日期 |
2016.12.29 |
申请号 |
SG11201609207S |
申请日期 |
2015.05.13 |
申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
WILSON, JAMES, M.;TRETIAKOVA, ANNA |
分类号 |
A61P31/12;C12N15/861 |
主分类号 |
A61P31/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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