METHOD OF FORMYL-L-PEPTIDES WINNING

摘要

This solution concerns substituted peptides, particularly N-formyl-L-peptides of the general formula: I : R - A - B - X, where R - formyl, A - Asp, Met, Ala-Ala, Phe; B - Phe, Leu; X -methyl - HN-C6H4 - n - NO2 which can be used in experimental biochemistry and medicine. "I" synthesis is carried out by condensation of N-formyl-substituted carboxylate composition (KK) of the general formula: R-A-OH with amine composition of the general formula: H-B-X, where R, A, B and X are introduced above, substituted in a carboxylate group. The process is done in the presence of (2.10<5>) up to (1.10<4>) mmol of metalloproteinase Bac. thermoproteolyticus per 1 mmol KK at pH 6.5 up to 8.0, at a temperature of 15 to 37 degrees Celsius in aqueous or water N,N-dimethylformamide atmosphere under a molar ratio at the amine composition and KK equal 1:1 to 2.