发明名称 |
VACCINATION AND METHODS AGAINST DISEASES RESULTING FROM PATHOGENIC RESPONSES BY SPECIFIC T CELL POPULATIONS |
摘要 |
2046909 9011294 PCTABS00002 The present invention provides vaccines and a means of vaccinating a mammal so as to prevent or control specific T cell mediated pathologies or to treat the unregulated replication of T cells. The vaccine is composed of a T cell receptor (TCR) or a fragment thereof corresponding to a TCR present on the surface of T cells mediating the pathology. The vaccine fragment can be a peptide corresponding to sequences of TCRs characteristic of the T cells mediating said pathology. Means of determining appropriate amino acid sequences for such vaccines are also provided. The vaccine is administered to the mammal in a manner that induces an immune response directed against the TCR of T cells mediating the pathology. This immune response down regulates or deletes the pathogenic T cells, thus ablating the disease pathogenesis. The invention additionally provides a specific .beta.-chain variable region of the T cell receptor, designated V.beta.17, which is central to the pathogenesis of rheumatoid arthritis (RA). Also provided are means to detect, prevent and treat RA.
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申请公布号 |
CA2046909(A1) |
申请公布日期 |
1990.09.22 |
申请号 |
CA19902046909 |
申请日期 |
1990.03.21 |
申请人 |
IMMUNE RESPONSE CORPORATION (THE) |
发明人 |
HOWELL, MARK D.;BROSTOFF, STEVEN W.;CARLO, DENNIS J. |
分类号 |
A61K39/00;A61K39/385;A61K39/395;A61K39/44;A61P25/00;A61P29/00;A61P35/00;A61P37/00;A61P43/00;C07K7/06;C07K14/00;C07K14/705;C07K14/725;C07K16/00;G01N33/564;G01N33/566;G01N33/68;(IPC1-7):C07K7/06;A61K43/00;A61K47/48;G01N33/554 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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