发明名称 A RAPIDLY CLEAVABLE SUBSTRATE FOR HIV PROTEASE
摘要 Hepta- to nona-peptides of the formula… A-B-C-D-E-Opr-F-G-H,… in which A is absent or is Val, Ile or Thr, B is Ser, Thr or Phe, D is Asp or Ala, E is Tyr or Phe, Opr is 5-oxaproline, F is Ile, Leu, Val, Thr or Gln, G is Val, Ile, Ser or Arg, and H is absent or is Gln, Glu, Pro or Thr, and the salts thereof are used for locating and detecting HIV protease and for testing possible inhibitors of HIV protease. They are prepared by known methods of peptide chemistry, preferably by means of solid-phase synthesis.
申请公布号 ZA8909556(B) 申请公布日期 1990.09.26
申请号 ZA19890009556 申请日期 1989.12.14
申请人 HOECHST AKTIENGESELLSCHAFT 发明人 KARIN MOELLING;STEPHAN HENKE;GERHARD BREIPOHL;WOLFGANG KOENIG
分类号 C07K1/04;C07K7/06;C07K14/16;C12Q1/37 主分类号 C07K1/04
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