OCTREOTIDE-PAMOATE AND ITS USE IN SUSTAINED RELEASE FORMULATIONS OF WATER SOLUBLE PEPTIDES

摘要

The present invention is directed to octreotide-pamoate which is suitable for use in sustained release formulations of a peptide drug compound preferably a somatosatin like octreotide, e.g. as a pamoate salt. The drug compound is present in a polymeric carrier, preferably a polylactide-co-glycolide, especially a poly(lactide-co- glycolide)glucose. The formulation is preferably a depot formulation in the form of a monolithic microparticle.